Connexin43 is dispensable for phagocytosis.

Bacterial Peritoneal Infection Phagocytosis and Host Survival after A Role for Connexin43 in Macrophage

The WD40 domain of ATG16L1 is required for its non‐canonical role in lipidation of LC3 at single membranes

A hallmark of macroautophagy is the covalent lipidation of LC3 and insertion into the double-membrane phagophore, which is driven by the ATG16L1/ATG5-ATG12 complex. In contrast, non-canonical autophagy is a pathway through which LC3 is lipidated and inserted into single membranes, particularly endolysosomal vacuoles during cell engulfment events such as LC3-associated phagocytosis. Factors cont...

Mechanisms and roles of phagocytosis in Drosophila and Caenorhabditis elegans

Our understanding of the humoral immune response in both vertebrates and invertebrates has dramatically deepened in the past decade. In contrast, many of the mechanisms and roles of the cellular immune response remain to be elucidated. Phagocytosis is at the center of the cellular responses in both innate and adaptive immunity. Targets of phagocytosis are either invading microbes or altered sel...

Biochemical analysis of connexin43 intracellular transport, phosphorylation, and assembly into gap junctional plaques

We previously demonstrated that the gap junction protein connexin43 is translated as a 42-kD protein (connexin43-NP) that is efficiently phosphorylated to a 46,000-Mr species (connexin43-P2) in gap junctional communication-competent, but not in communication-deficient, cells. In this study, we used a combination of metabolic radiolabeling and immunoprecipitation to investigate the assembly of c...

بررسی فعالیت ماکروفاژهای صفاقی موش C57BL/6 پس از فاگوسیتوز سلول‌های بنیادی مزانشیمی ژله وارتون آپوپتوز شده

Background: Macrophages are one of the most important immune cells. Macrophages can be divided into two main subgroups of classical or inflammatory macrophages(M1) and alternative or non -inflammatory macrophages or (M2), due to different stimuli. One of the factors that causes the macrophage to orient towards M2, is the phagocytosis of apoptosis cells (efferocytosis). The phagocytosis of mesen...